Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p052 | (1) | WCRB2014

Production of prion gene knockout cow to prevent spontaneous bovine spongiform encephalopathy

Manabe Noboru , Onoyama Ichiro , Li Junyou , Sendai Yutaka , Aoyagi Yoshito

Introduction: In 1986, typical borine spongiform encephalopathy (BSE) was found in UK. Cattle were orally given abnormal prion protein in the brain of sheep with Scrapie. Orally administered abnormal prion protein causes variant type Creutzfeldt-Jakob disease infection in human. In 2003, spontaneous BSE was found in many countries. Spontaneous BSE is transmissible from cattle to monkey. In 2012, United States Department of Agriculture reported that spontaneous BSE cow was foun...

ra0001p115 | (1) | WCRB2014

Critical role of decoy receptor 3 in regulation of granulosa cell apoptosis in pig ovarian follicle

Fukumoto Yoshinosuke , Sugimoto Miki , Onoyama Ichiro , Wongpanit Kannika , Manabe Noboru

Introduction: During follicular development in mammalian ovaries, the majority of follicles undergo atresia. One of the characteristics of this process is apoptotic cell death in granulosa cells. Death ligands and receptors, including Fas ligand (FasL) and Fas, have been detected in follicles and also demonstrated to be capable of inducing apoptosis in follicular cells. Decoy receptor 3 (DcR3) competes with Fas to bind FasL but lacks intracellular death domains, thus inhibitin...